This study comparatively examines state policies of university autonomy in the Eastern Neighborhood countries of the European Union, with a particular focus on Georgia, Ukraine, and Moldova. Guided by the principles outlined in the 2007 Lisbon Declaration, the research investigates how university autonomy is shaped by state policies in these three countries. The study is grounded in the qualitative research design, drawing on document analysis, semi-structured interviews, and content analysis of legislative frameworks and higher education experts’ perspectives- including those of professors and administrative personnel. Five core features of university autonomy policies were identified: Legislative control over university autonomy, Political appointments to administrative positions, gaps between policymaking and implementation, the impact of funding on financial autonomy, and the existence of formal rather than substantive academic autonomy in relation to quality assurance standards. Two primary explanatory factors emerged: the scarcity of university resources and the persistence of centralized management practices. The study is framed through systems theory, drawing on the work of Alex Clark, Michael Hogg, and Ron Stewart in University Autonomy and Public Policy: A Systems Theory Perspective. From this perspective, universities, government bodies, and policymakers are understood as interdependent components of the broader systemic network, where actions taken by one entity influence the functioning of others. This research contributes to the limited academic literature on university autonomy in the EU’s Eastern Neighborhood by offering a cross-country comparison aligned with European higher education standards.